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HPV Test Better At Finding Cervical Cancer, Study Says

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The Associated Press

Published: October 18, 2007

NEW YORK - A relatively new screening test was about twice as accurate as the traditional Pap smear at spotting cervical cancer, according to the first rigorous study of the test in North America.

The new test could replace the 50-year-old Pap in a matter of years, experts say. There's also a bonus for women: They won't need a screening test as often.

The HPV test, which looks for the virus that causes cervical cancer, correctly spotted 95 percent of the cancers. The Pap test, which checks for abnormal cells under a microscope, only found 55 percent, according to researchers at McGill University in Montreal, who published their findings in the New England Journal of Medicine.

'We've had the Pap test for over 50 years and it's high time it be replaced by technology that's more robust,' said Eduardo Franco, director of McGill's division of cancer epidemiology, who led the study.

Franco said some feared the HPV test would result in more false alarms, causing anxiety and requiring more follow-up testing. In the study, there were only slightly more false positives for the HPV tests (6 percent) than the Pap smears (3 percent).

HPV, or human papilloma virus, is a common sexually transmitted disease. Infections are mostly in young women and most go away on their own. The HPV test looks for the high-risk viruses that can cause cervical cancer if the infection persists. Like the Pap, it uses cells scraped from the cervix, the lower part of the uterus.

Because the Pap test misses about half of the cases, doctors use frequent testing to catch the slow developing cancer at its earliest, most treatable stages.

The HPV test has been available in the United States since 2000 and was first used for inconclusive Pap tests. Now women over 30 can get an HPV test - but only along with a Pap - and wait three years to be tested again if both tests are negative.

More recently, scientists have been studying whether the HPV test can be used alone. Debbie Saslow, director of breast and gynecologic cancer for the American Cancer Society, said a number of studies support using the HPV test in place of a Pap.

'Overall, I don't think there's any doubt that HPV testing has a lot of advantages over the Pap test,' she said.

In the United States, Medicare pays about $50 for the HPV test and $15 to $28 for a Pap test.

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